Cindy Cheng
Senior Category $8000 Award
Waterloo-Wellington – ON
3D Bioprinting Soft Microrobotic Niches for Stem Cell Delivery
Stem cell therapy holds tremendous promise for treating illnesses by regenerating body tissues, but struggle to be approved due to unsafe and inefficient delivery methods. To address this, the Soft MicroRobotic “nichE” (SMORE) system was develope ...
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Stem cell therapy holds tremendous promise for treating illnesses by regenerating body tissues, but struggle to be approved due to unsafe and inefficient delivery methods. To address this, the Soft MicroRobotic “nichE” (SMORE) system was developed, which employs soft microrobots that mimic the body’s stem cell reservoirs to deliver large amounts of stem cells while promoting their healthy survival and integration. The microrobots were 3D-bioprinted from liquid cell-laden inks composed of a biocompatible polymer, a light-reactive initiator, magnetic nanoparticles, stem cells, and niche components. The material and formulation process was found to be suitably porous, elastic, and biocompatible for supporting live cells and microrobots demonstrated injectability and responsivity in navigating through a spinal model. As such, the system exhibits potential for overcoming the primary obstacles to efficient cell delivery, offering a pathway towards highly effective stem cell therapies that can transform the treatment of countless diseases. My Projectboard.
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